Mg2+ Homeostasis: The Mg2+nificent TRPM Chanzymes
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منابع مشابه
Mg2+ Homeostasis: The Mg2+nificent TRPM Chanzymes
TRPM6 and TRPM7 are distinct from all other ion channels in that they are composed of linked channel and protein kinase domains. Recent studies demonstrate that these 'chanzymes' are essential for Mg(2+) homeostasis, which is critical for human health and cell viability.
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Over the past decades, the clinical relevance and biological significance of Mg2+ have been thoroughly documented. Although multiple Mg2+-transport pathways have been biophysically characterized, the molecular identity of the postulated components of Mg2+-homeostasis regulation in vertebrates remain undefined. Recent advances in the fields of genetics, genomics and proteomics, and novel technol...
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ژورنال
عنوان ژورنال: Current Biology
سال: 2003
ISSN: 0960-9822
DOI: 10.1016/j.cub.2003.09.048